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If the TB skin take a look at is used for baseline testing of U.S. health care personnel, use two-step testing. When given a TB pores and skin take a look at years after an infection, these individuals may have little or no response, giving a adverse pores and skin take a look at outcome. It can also happen in individuals of any age who’ve been vaccinated with BCG or infected with mycobacteria in addition to M. Multiple BCG doses (as practiced in some countries) will increase a person’s sensitivity to the TB skin check and the duration of positive TB skin take a look at results after BCG administration. TB pores and skin check reactions must be interpreted based mostly on danger stratification regardless of BCG vaccination historical past. TB pores and skin check reactivity caused by BCG vaccine usually wanes with the passage of time, but periodic pores and skin testing may delay (boost) reactivity in vaccinated individuals.


